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Vitamin B-12 is the source of coenzymes for the respective methylation of homocysteine by 5-methyltetrahydrofolate (5-methylTHF) to form methionine and for the mitochondrial conversion of methylmalonyl-CoA to succinyl-CoA ( Figure 1 )

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Practical Implications of No IGF-1 Elevation: The absence of IGF-1 stimulation makes AOD-9604 suitable for populations who need to avoid IGF-1 elevation, including individuals with personal or family history of hormone-sensitive cancers, those concerned about accelerated aging through growth pathway activation, people seeking fat loss without anabolic muscle-building effects, individuals who have contraindications to growth hormone therapy, and those undergoing screening or monitoring where IGF-1 elevation would be problematic