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The World Natural Bodybuilding Federation specifically prohibits peptides including ipamorelin, CJC-1295 DAC, hexarelin, sermorelin, GHRP-2, GHRP-6, and MK-677

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In experimental models, it appears to interact with several pathways central to tissue integrity and repair

The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling