Furthermore, vitamin D also showed significant inhibition of NF-B pathways (181), and a regulatory effect regarding cytokine production, thus it inhibits proinflammatory cytokines in SLE pathogenesis, including IFN-, IL-17, IL-23, IL-6, and TNF- (182184), while stimulating anti-inflammatory cytokine production like IL-10 and TGF- (185, 186)
The improvement stems from restored cellular metabolism rather than weight loss alone
10.1016/j.mvr.2023.104510 Kay P, Yang YC, Hiscott P, Gray D, Maminishkis A, Paraoan L: Age-related changes of cystatin C expression and polarized secretion by retinal pigment epithelium: potential age-related macular degeneration links
BL endowed with high-affinity binding to ROS, demonstrating exceptional efficiency in scavenging oxidizing agents (Thomas et al., 2022)