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Additionally, exosomes from MSCs (MSC-Exos) can suppress inflammation, restore key cellular functions,and initiate tissue repair and regeneration.An animal experiment reported that after delivering exosomes into the brain of VPA-induced autistic mice via intranasal administration, the mice exhibited improved self-grooming and reduced repetitive standing behaviors, increased time spent exploring unfamiliar mice, decreased levels of pro-inflammatory cytokines IL-1, TNF-, and IL-6, and increased levels of the anti-inflammatory cytokine IL-10 (172)

Critical role of FoxO1 in granulosa cell apoptosis caused by oxidative stress and protective effects of grape seed procyanidin B2

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Oncogene 24 , 47364740 (2005)