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however, the ferroptosis stress is alleviated with supraphysiological cystine supplement, though under which the TSS pathway is nonfunctional

those retaining sulfur in the reduced state, namely 3MP and H 2 S (the latter provided by the H 2 S donor Na 2 S) did fully reproduce the phenomenon, and both were even more effective than Cys in doing so (Figure 1C-D)

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The objective is not to achieve the lowest possible homocysteine concentration, but to support efficient methylation and healthy one-carbon metabolism