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Single and multiple-dose pharmacokinetics of varenicline have been investigated in pediatric patients aged 12 to 17 years old (inclusive) and were approximately dose-proportional over the 0.5 mg to 2 mg daily dose range studied

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Shalizi and Thomas, 2010), and we believe that our comparison of results from different statistical approaches (regressions, CLPMs, and SIENA) is a strength of this paper