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Adolescent THC exposure causes enduring prefrontal cortical disruption of GABAergic inhibition and dysregulation of sub-cortical dopamine function

Accordingly, selective targeting of GSH-dependent nodes (such as cysteine transport, mitochondrial GSH import, compartmentalized GSH degradation, or NADPH-dependent regeneration) may offer greater specificity and efficacy than indiscriminate redox perturbation

Inhibition of the catalytic activity of rhodanese by S-nitrosylation using nitric oxide donors

However, these procedures are not only ineffective in the long term but also exhibit inherent issues such as limited spinal motion and accelerated degeneration of adjacent intervertebral discs