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Extracellular GSH concentrations in the brain are very low (Hilgier et al

Gonzalez-Iglesias H, Alvarez L, Garca M et al (2014) Metallothioneins (MTs) in the human eye: a perspective article on the zinc-MT redox cycle

An increase in SOD activity points to an adaptive response in urticaria patients, but the reserves of other antioxidants that scavenge ROS can become depleted as the diseases progresses