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Bibcode:2007PNAS..104.8685G

Based on the target prediction analysis, they found that miR-657 indeed bound to IGF-1R 3UTR and miR-675 overexpression reduced the cell proliferation in embryonic and extra-embryonic cell lines, suggesting that miR-675 is involved in the H19 -mediated developmental control by targeting IGF-1R

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What preclinical research has documented are indirect interactions with several neurochemical systems: Indirect opioid system engagement