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In the first enzyme reaction, methylcobalamin is used to recycle the folate cofactor 5-methyltetrahydrofolate to tetrahydrofolate thereby allowing the folate cofactor to participate in a cycle involving the biosynthesis of purines and pyrimidines

even lower exposure beat placebo for weight loss in early trials. The 2.4 mg maintenance dose sits on the shoulder of the effect curve rather than at a hard ceiling

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Find out why malabsorption is happening Choose the best treatment method (e.g., injections, sublingual tablets) Keep an eye on how the patient is doing and adjust treatment if needed Medication-Induced B12 Deficiency Management Medication can also cause B12 deficiency