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Nicotine-based mechanisms have also been proposed, including modulation of ACE2 expression and engagement of cholinergic anti-inflammatory pathways

Association of promoter variants in the 7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia

Furthermore, risk was elevated in those using predominantly high-potency resin (RR 2.11, compared to PWUC using herbal cannabis), those mixing cannabis with tobacco (RR 2.15, compared to PWUC not mixing with tobacco) and those with a diagnosis of psychosis (RR 14.01), bipolar (RR 4.30), anxiety (RR 2.92) and depression (RR 2.68), compared to individuals without a mental health diagnosis

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