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[89] indicated that 2M was increased in COPD patients and was correlated with lower pulmonary diffusing capacity values, increased alveolar wall/septal thickening (fibrosis changes), and higher expressions of TGF-1, Smad4, and a-SMA

Furthermore, an ECM appropriate for analyzing relationships between variables with these characteristics produced a similar estimate: every 1-unit increase in per-capita ENDS sales is associated with a 1.5 packs-per-capita shortfall in cigarette sales (see Supplementary Analysis 1)

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