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Specifically, in secretion-competent INS-1E cells and isolated mouse islets (186), butyrate significantly attenuates IL-1- or IL-1/IFN--induced apoptosis by suppressing endoplasmic reticulum (ER) stress, while reducing the production of nitric oxide (NO) and chemokines (CXCL1, CXCL10) that amplify immune cell infiltration

48 In the Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (SURMOUNT-5) trial in adult participants with obesity but without T2DM, tirzepatide (10 mg or 15 mg) achieved greater weight loss compared with semaglutide (1.7 mg or 2.4 mg weekly dose): 20.2% (95% CI 21.4 to 19.1) versus -13.7% (95% CI 14.9 to 12.6) at week 72