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When this barrier is disrupted, RPE cell activation occurs, leading to the proliferation, epithelial-mesenchymal transition (EMT), and secretion of extracellular matrix molecules, thus promoting vitreoretinal disorders, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and proliferative diabetic retinopathy (PDR) [1,2,3]

It is the largest group of geysers in the southern hemisphere and the third largest in the world, after Yellowstone and Kronotski Nature Reserve, whose fumaroles create impressive plumes of steam that can be seen between 6 and 7 in the morning

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