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Overall, the targeted delivery, immune modulation, and tumor-inhibitory capabilities of modified EVs have been firmly established

Exogenous transferrin cannot donate iron to intestinal mucosal cells (Bezwoda et al., 1986), and the brush boarder membrance lacks transferrin receptors (Parmley et al., 1985) (although they are present on the basolateral surface of intestinal epithelial cells (Levin et al., 1984)

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Additionally, the results of cognitive ability tests suggested that curcumin treatment had limited benefits on cognitive function, as shown by better scores in measures of sustained attention and working memory compared to placebo (97)