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Given an assumed effect size of 1.8 derived from a meta-analysis of mHealth SC RCTs (RR=1.83) 30 , power of 80% and an allocation ratio of 1:1, the required sample size for detecting a significant difference in biochemically validated abstinence rates between the intervention group and control group at two-sided type I error of 0.05 is 664 (each group 332)

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Fish with the common torpedo shape are often very streamlined and excellent swimmers