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however, most tissues contain vitamin C at much higher concentrations, ranging from 15 mM, and neurons contain vitamin C at concentrations of 10 mM or greater (Higdon et al

We illustrate significance in the figures of this manuscript with the following conventions: p 0.05 is denoted with *, p 0.01 is denoted with ** and p 0.001 is denoted with ***

Bioinformatics analysis indicated that the riboflavin deficiency caused an up-regulation of Parkinsons disease pathway, steroid catabolism, endoplasmic reticulum stress and apoptotic process, while the fatty acid metabolism, tricarboxylic citrate cycle, oxidative phosphorylation and iron metabolism were down-regulated

178,179,180 In 2004, the FDA approved the first aptamer drug, pegaptanib (Macugen), to treat choroidal neovascularization caused by neovascular age-related macular degeneration (AMD)