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Glossary ACC1 Acetyl-CoA carboxylase 1 ALD Alcoholic liver disease ALP Alkaline phosphatase ALT Alanine aminotransferase AMPK AMP-activated protein kinase AST Aspartate aminotransferase CARM1 Coactivator-associated arginine methyltransferase 1 DIC Diclofenac DILI Drug-Induced Liver Injury EGCG epigallocatechin-3-gallate EGFR Epidermal growth factor receptor EMT Epithelial-mesenchymal FATP 2 fatty acid transport protein 2 FFA Frontal fibrosing alopecia GA Gallic acid -GT Gamma-glutamyl transferase HA Hyaluronic acid HCC Hepatocellular carcinoma HFD High-fat diet IL-1 Interleukin 1 IL-6 Interleukin 6 LNCs Lipid nanocapsules LXR- Liver X receptor-alpha MDA Malondialdehyde MMP-2 Matrix metalloproteinases-2 NAFLD Non-alcoholic fatty liver disease NF-B Nuclear factor kappa B Nrf2 Nuclear factor erythroid 2-related factor 4-OMeGA 4-O-methyl gallic acid PELP1 Proline, glutamate, and leucine-rich protein 1 PGG Penta-o-galloyl--D-glucose PI3K Phosphoinositol-3 kinase PON1 Paraoxonase1 PPAR- Peroxisome proliferator-activated receptor alpha RMLNC Reverse micellar-loaded lipid nanocapsules SA Sodium nitrite SREBP-1c Sterol regulatory element-binding protein-1c TAA Thioacetamide TG Triglyceride TGF- Transforming growth factor-beta TIMP-1 Tissue inhibitor of matrix metalloproteinases-1 TNF Tumor necrosis factor alpha References 1 AbenavoliL.LarussaT.CoreaA.ProcopioA

In addition to activation by PERK as part of the UPR, eIF2-ATF4 can also be activated by other stress sensors, including GCN2, PKR and HRI, collectively referred to as the Integrated Stress Response (ISR) 46

The results of these research studies indicate the involvement of the ANG gene in ALS pathogenesis (Conforti et al