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TGF- is an important regulator of neovascularization in tumor and it acts in a context-dependent manner by promoting angiogenesis via stimulation of pro-angiogenic factors like VEGF or inhibiting tumor angiogenesis by impairing endothelial cell proliferation and migration or by inducing apoptosis [211]

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The pace and quality of this cycle are orchestrated largely by the dermal papilla , a cluster of specialized mesenchymal cells at the base of the follicle that signals to the surrounding matrix and stem-cell compartment