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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

Graf, M., & Christen, H

It also appears in peripheral organs and body fluids, suggesting systemic regulatory functions beyond the central nervous system

Second, administration route matters: Matrixyl is limited to topical application, while GHK-Cus water solubility and established injectable safety data expand the research design space considerably