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CYP1-4 enzymes play an important role in the oxidative metabolism of fatty acids, steroids, polycyclic aromatic hydrocarbons (PAHs), various drugs such as acetaminophen, caffeine, clozapine, phenacetin, clomipramine and naproxen, and other carcinogens and environmental pollutants 73,74

1 The ESC also suggests that pioglitazone should be considered for reducing ASCVD risk in patients with T2D with ASCVD based on the data and net benefit-risk assessment

Interestingly, it is also common to diagnose irAEs even after the discontinuation of ICI agents

Discontinue use immediately if you experience adverse effects, including skin irritation, pain, or other concerning symptoms, and seek medical advice as appropriate