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The latter is characterized by glomerular hyperfiltration, glomerular/tubular hypertrophy, and thickening of the glomerular basement membrane and mesangial matrix expansion/proliferation, resulting in increased glomerular permeability with consecutive albuminuria and progressive CKD [195]

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133 Caspase-1 is a key effector molecule downstream of inflammasome activation and plays a central role in processing and releasing proinflammatory cytokines, such as IL-1 and IL-18

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