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Chronic oxidative stress in synovial T-lymphocytes of patients with RA results from intracellular ROS production (mainly H 2 O 2 ) (194), and ROS may be involved in destructive pathological events of RA

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Sulfites are also present in many oral medications (adrenaline, isoprenaline, isoproterenol, isoetharine, phenylephrine, dexamethasone and injectable corticosteroids, dopamine, local anaesthetics, propofol, aminoglycoside antibiotics, metoclopramide and doxycycline) and topical creams and ointments (antifungals and corticosteroids)

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