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Advanced experimental techniques, including spatial transcriptome, single-cell (or nuclei) transcriptomics and assay for transposase-accessible chromatin using sequencing, will be instrumental in uncovering the epigenetic and transcriptomic signatures associated with the transformation of astrocytes under neurodegenerative conditions 156

Other recent studies have investigated the lipidomic profile of arthritis patients in different phases of the disease to understand the correlation between lipid alteration and the severity of local inflammation (188190)

These two work together to fight against oxidation that would otherwise block NOS due to oxidation