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Evidence of abnormal mitochondrial ultrastructure in hepatocytes of patients with Wilsons disease supports the theory that mitochondria are one of the affected organelles in copper toxicity.17 There is also evidence to suggest that the mechanism of hepatocyte death in Wilsons disease is via apoptosis that may explain the typical mild elevation in the transaminases associated with hepatitis in Wilsons disease.18 Clinical Presentation One of the challenges of diagnosing Wilsons disease is the wide spectrum of clinical presentations

Funding: This publication is part of the project ROBUST: Trustworthy AI-based Systems for Sustainable Growth with project number KICH3.LTP.20.006, which is (partly) financed by the Dutch Research Council (NWO), Philips Medical Systems Nederland B.V., and the Dutch Ministry of Economic Affairs and Climate Policy (EZK) under the program LTP KIC 2020-2023

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In addition, the efficacy and safety of cabozantinib + nivolumab for patients with advanced HCC were first presented at 2020 ASCO Gastrointestinal Cancer Symposium