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long-term safety isnt fully established
However, if feeling worse lasts more than a few days, this could be due to overmethylation, other gene variations such as an expressed CBS gene variation that may need to be supported before adding methylation support, or a sensitivity to the supplements, and the supplements should be discontinued
The HLA molecule, normally found on the antigen-presenting cell (APC), attachs and reveals an antigenic peptide, enabling the T cell to recognize and respond to an antigen