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Michael LaFaive of the center estimated that the state could havelost as much as $1.8 billion in 2011 as a result

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A major UK clinical trial found that, when combined with expert face-to-face support, people who used e-cigarettes to quit were twice as likely to succeed than people who used other nicotine replacement products such as patches or gum [footnote 61]

Therefore, if there is insufficient blood flow to the brain to meet metabolic demands, the brain will experience hypoxia