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lncRNA SEMA5A-IT1 Myocardial cell I/R injury is a common complication during cardiopulmonary bypass (CPB) cardiac surgery

Such channel modifications alter ion flow, transmembrane potential, and reduce both APD and conduction velocity, ultimately disrupting cardiac electrophysiological activity and elevating the risk of arrhythmias ( The HCN channel, also known as the If channel, is activated near the end of the repolarization phase, enabling inward currents mediated by Na + and K + throughout diastolic depolarization (Rivolta et al., 2020)

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A larger double-blind, placebo-controlled, multicenter trial targeting aging with metformin plans to enroll 3000 patients between the ages of 65 and 79 as the primary endpoint before any aging-related diseases develop