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Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

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Using a simple sono-chemical technique, the multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) were successfully synthesized from folic acid (FA) functionalized thiolated chitosan and effectively applied for various diagnostic and therapeutic purposes in bio-medicine (Guo Y

, fluoxetine (78) sertraline (79), promote remission in acute experimental autoimmune encephalomyelitis) BPC 157 affects with region specific influence the brain serotonin synthesis (-[14C]methyl-l-tryptophan autoradiographic measurements) (80), reduces the duration of immobility to a greater extent than imipramine (81)