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As previously reported, women with a history of PE are at an increased risk of long-term coronary heart disease, heart failure, stroke, and cardiovascular disease-related death later in life 3 , and their offspring are also at an elevated risk of hypertension and cardiovascular disease 4

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305,306 For instance, histone Kla, especially H3K18la, facilitates the expression of the m 6 A reader protein YTHDF2, leading to the degradation of m 6 A-modified mRNAs such as PER1 and TP53 , which promotes tumor growth in OCM1 and CRMM1 cells

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