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The intricate balance between pro-inflammatory and anti-inflammatory mechanisms is central to the development and progression of ulcerative colitis

Nevertheless, a major unresolved question remains how metabolic and subcellular regulation of GSH intersects with inflammasome signaling to dictate context-dependent pyroptotic cell fate

doi:10.1093/ofid/ofw196

Combined, these results suggest that glutathione is an important host resistance mechanism, but that also and ability to withstand host ROS, and potentially use this as a trigger for zoospore production, is important for Bd virulence