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Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hSOD1 models of amyotrophic lateral sclerosis by activating ERK

Exposure to various environmental stressors, such as tobacco toxins, induces ferritinophagy and ferroptosis in BMSCs, which increases labile iron and ROS, thereby impairing osteoblastic differentiationproviding a mechanistic basis for smoking-associated age-related bone loss ( Postmenopausal osteoporosis Osteoporosis factors related to aging are also implicated in postmenopausal osteoporosis (42, 43)