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The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and Proteins) and induced pathologies

The hallmark of ferroptosis is iron-dependent lipid peroxidation, particularly of polyunsaturated fatty acid (PUFA)-phospholipids (PLs), accompanied by characteristic mitochondrial morphological changes such as shrinkage, loss or reduction of mitochondrial cristae and increased mitochondrial membrane density

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