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Figure 1 3 Renal regulation of vitamin D metabolism and its alterations in CKD 3.1 Physiological regulation of vitamin D metabolism in the kidney The kidney plays a central role in the activation of vitamin D

doi: 10.3389/fmed.2021.754667 250 XieYChoiTAl-AlyZ

Roman, P., Estvez, A.F., Miras, A

63 suggested that arbutin primarily relies on the hydroxyphenyl part to form - stacking with histidines around the metal site, stabilizing its binding