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10.1111/j.1471-4159.2009.06145.x 243 StastnyD.VogelR

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

Based on the abundance of neutrophils in bone and their known contributions to cancer progression [8], we previously investigated the role of neutrophils in the prostate tumor-bone microenvironment

10.3390/biom5042247 Biomolecules