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2 Activation of the GHR and GHR-stimulated signal transduction pathways has been comprehensively reviewed elsewhere, and we refer the reader to recent reviews for a more detailed description of GHR-mediated signaling

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Activated PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which functions as a second messenger, recruiting AKT and PDK1 to the plasma membrane