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A 2011 study by Rubinstein et al suggests that as smokers get used to this regular use of dopamine, natural reinforcers of dopamine such as food become less powerful: ...even at low levels of nicotine exposure, brain regions linked to reward have decreased responses to pleasurable food images compared with nonsmokers. Does vaping help you lose weight

This would seem to suggest that some of these changes, or perhaps all of the changes combined (e.g., both xCT and GLT-1) are necessary to reverse the behavioral outcomes of chronic cigarette smoke exposure

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