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Glial cells, including microglia and astrocytes, support and regulate neurons, but excessive glial proliferation or impaired regulation can cause problems

Summary: No, coffee enemas do not help fatty liver disease and carry significant health risks including rectal perforation, electrolyte disturbances, and infection

Some researchers use a third for the injection site

however, available evidence from repeated-dose animal studies and clinical observations suggests a favorable safety margin, with no evidence of dependence, tolerance, or withdrawal phenomena (6)