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Lactate produced by bacterial community serves as a critical energy substrate for other commensal bacteria, such as butyrate-producing species within Clostridium groups XIVa and IV (e.g., Faecalibacterium and Roseburia ) [246, 247]
The transcription factor Nrf2 is a potent transcriptional activator that plays a central role in the inducible expression of many cytoprotective genes in response to oxidative and electrophilic stresses ( Figure 1 )
In cynomolgus monkeys, intra-ovarian injection of human embryonic stem cellderived MSC-like M cells reduced fibrosis and DNA damage, restored sex-steroid secretion, and supported the birth of a healthy infant, changes substantiated by single-cell RNA sequencing that showed dampened oxidative stress and inflammation in granulosa and stromal compartments [192]
In vivo testing of orally delivered nanoparticles, in Nanotechnology for oral drug delivery , 459480
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