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In line with the effect of LD on the collagen fibers, this group, later on, discovered that the MMP-2 protein expression was significantly reduced in rats treated with LD with an increased tissue inhibitor of metalloproteinase-2 (TIMP-2) expression, suggesting the influence of LD on the ECM (Wang et al., 2016)

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It has not been evaluated for safety or efficacy in humans, and no conclusions should be drawn regarding potential clinical applications

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