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et al., 2023), retarding renal fibrosis through regulating HGF and TGF-/Smad signaling pathway (Ma et al., 2018), hindering EMT via regulation of bone morphogenetic protein-7/TGF-1 in renal fibrosis (Wang et al., 2007), and improving renal fibrosis in CKD by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 ( Interestingly, deoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin (Xu et al., 2022)
In agreement with these results, calves from RPM-supplemented cows experienced alteration in Met metabolism to favor the synthesis of taurine and glutathione, suggesting an advantage for controlling metabolic-related stress (Jacometo et al., 2017)
Group B (moderate-ineffective group): A total of 8 patients, including 4 males (50.0%) and 4 females (50.0%)