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Keeping glutathione levels where they need to be under that kind of combined demand doesn't happen by default

Expert Opin Ther Pat 28:197210 Cioffi CL, Wolf MA, Guzzo PR, Sadalapure K, Parthasarathy V, Dethe D, Maeng J-H, Carulli E, Loong DT, Fang X (2013) Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl) piperazin-1-yl) cycloalkyl) methyl) benzamide inhibitors of glycine transporter-1

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The levels of malondialdehyde (MDA) (A003-1-2), glutathione peroxidase (GSH-Px) (A005-1-2), catalase (CAT) (A007-1-1), nitric oxide (NO) (A012-1-2), superoxide dismutase (SOD) (A001-3-2), corticosterone, and total antioxidant capacity (T-AOC) (A015-2-1) were measured using a kit from the Nanjing Jiancheng Bioengineering Institute