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Chronic exposure to elevated reactive oxygen species (ROS) levels induces DNA damage response (DDR), potentially leading to the formation of extrachromosomal DNA (ecDNA)

Nanoparticle properties modulate their attachment and effect on carrier red blood cells

The field has been facing a growing interest in the past decade

However, since a diagnosis of apoptosis implies a specific sequence of biochemical and morphological events and should ideally be supported by electron microscopy, it may be more prudent to diagnose single cell necrosis unless there is definitive proof of apoptosis provided by electron microscopy (Levin et al