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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

(Calculations based on a 60 kg patient.) Mutagenicity assays did not reveal any valsartan-related effects at either the gene or chromosome level

These elements are necessary for the secretion of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1), which ultimately decreases the expression of VEGF compared to the diabetic group without DFU and interrupts the wound healing process in diabetic patients (101)

The skin after scraping off the characteristic scales is smooth and shiny