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discovered that miR-1249-3p is significantly upregulated in Natural killer (NK) cells-derived exosomes from lean mice, which directly targets SKI family transcriptional corepressor 1 (SKOR1), subsequently downregulated the expression levels of pro-inflammatory cytokine factors (including IL-1, IL-6, and TNF-) levels and attenuated IR

(Adapted from Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ

We also thank Frank von Delft and XChem group members, including Lizb Koekemoer, Anthony Aimon, Warren Thomson, Ruben Sanchez Garcia, William Bradshaw, Conor Wild, Mihaela Smilova, Charlie Tomlinson, Romain Talon and the I04-1 beamline scientists for their guidance

Personalized cancer vaccines: targeting the cancer mutanome