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Clinical studies suggest that these granules, when combined with L-T4, can significantly lower TPOAb and TGAb titers, Th17 cells, and relevant cytokines compared to L-T4 treatment alone, while also enhancing the Treg/Th17 ratio, representing another intervention with supporting clinical evidence (Cao et al

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Considering that D-Glu 20 can target an attached cargo specifically to any exposed hydroxyapatite (5), one can hypothesize that D-Glu 20 should be capable of delivering a therapeutic or imaging agent to any traumatized tissue where hydroxyapatite is exposed