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In the FSL rats, a combined treatment with sodium salicylate, which is a non-selective inhibitor of NF-B, counteracted the antidepressant effect of LAC on the expression of mGlu2 receptors, supporting the link between LAC-mediated mGlu2 induction and p65/NF-B [30]

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One study even suggested that long-term alpha-GPC consumption in mice kept aging-related cognitive decline to a minimum.52 However, more in-depth studies are needed on human subjects before this potential benefit can be considered legitimate or not