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Two-dimensional molecular plasticizer structures were designed using Marvin 17.21.0, ChemAxon and are shown in (S.Fig

While TEAEs, grade 3 or higher TEAEs, TEAEs associated with fatal outcome, and serious adverse events (SAEs) appeared similar to placebo, there was a higher rate of drug discontinuation (20.4% versus 8.6%), dose interruption (34.0% versus 20.1%), and dose reduction (18.9% versus 6.3%) due to TEAEs for VANFLYTA compared to placebo and we would appreciate additional information regarding these differences

They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)