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Upon acetaminophen challenge, cholestyramine-fed mice showed impaired hepatic glutathione regeneration capacity and markedly worsened liver injury, which was fully prevented by N-acetylcysteine administration

The luminal surface cells of the intestinal epithelium originate from intestinal stem cells (iSCs) and comprise various cell types, including enterocytes, goblet cells, enteroendocrine cells, tuft cells, and Paneth cells