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L-NAME+L-arginine (combined) exhibited a decrease in bleeding amount and laboratory values in comparison to controls (amputation only) or control-heparin and control-warfarin groups

The method of any one of embodiments 1-61, wherein the therapeutic agent is essentially in the form of micronized particles

Abstract The involvement of cellular senescence in the initiation and propagation of diseases is clearly characterized, making the elimination of senescent cells essential to treat age-related diseases

Therefore, the identification of new endogenous analgesic peptides is critical to understand the process of nociception and to develop novel strategies for the treatment of chronic pathological pain